Journal
TETRAHEDRON LETTERS
Volume 43, Issue 42, Pages 7589-7591Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(02)01822-1
Keywords
protecting group; tetrahydropyranyl; heteropolyacids; Wells-Dawson catalyst; alcohols; phenols
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A simple and efficient procedure to form 2-tetrahydropyranyl acetals of phenols and alcohols is reported. Wells-Dawson heteropolyacid catalyst is used both in bulk form or supported on silica, reaction conditions include room temperature and toluene as solvent. Fast deprotection of THP-acetals can be attained by mere change of the solvent using THF-1% MeOH. In both reactions the supported catalyst is easily recoverable and reusable, and the yields are good to excellent. (C) 2002 Elsevier Science Ltd. All rights reserved.
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