Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 99, Issue 21, Pages 13477-13480Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.162504299
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Funding
- NIAID NIH HHS [R01 AI021144, AI-21144] Funding Source: Medline
- NIGMS NIH HHS [R01 GM036659, GM-36659, R37 GM036659] Funding Source: Medline
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Electron microscopy of the RSC chromatin-remodeling complex reveals a ring of protein densities around a central cavity. The size and shape of the cavity correspond closely to those of a nucleosome. Results of nuclease protection analysis are consistent with nucleosome binding in the cavity. Such binding could explain the ability of RSC to expose nucleosomal DNA in the presence of ATP without loss of associated histones.
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