Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 33, Issue 8, Pages 1021-1025Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0891-5849(02)00857-2
Keywords
protein oxidation; aging; C elegans; age-1; daf-2; mev-1; energy metabolism; free radicals
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The nematode Caenorhabditis elegans has proven a robust genetic model for studies of aging, including the roles of oxidative stress and protein damage. In this review, we focus on the genetics of select long-lived (e.g., age-1, daf-2, daf-16) and short-lived (e.g., mev-1) mutants that have proven useful in revealing the relationships that exist among oxidative stress, life span, and protein oxidation. The former are known to control an insulin/IGF-1-like pathway in C. elegans, while the latter affect mitochondrial function. (C) 2002 Elsevier Science Inc.
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