Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 99, Issue 21, Pages 13908-13913Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.212504599
Keywords
CRF; CRH; inhibitory avoidance; memory storage; neuropeptide
Categories
Funding
- NIMH NIH HHS [MH 12526, R01 MH012526, R56 MH012526] Funding Source: Medline
- NINDS NIH HHS [R01 NS039307, NS 28912, R01 NS028912, NS 39307] Funding Source: Medline
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It is well established that adrenal stress hormone-induced activation of the basolateral complex of the amygdala (BLA) influences memory consolidation. The present experiments investigated the involvement of corticotropin-releasing hormone (CRH) in the BLA in modulating memory consolidation. Bilateral infusions of the CRH receptor antagonist [9-41]-alpha-helical CRH (0.3, 1.0, or 3.0 mug in 0.2 mul) administered into the BLA of male Sprague-Dawley rats immediately after aversively motivated inhibitory avoidance training produced dose-dependent impairment of 48-h retention performance. Because the CRH receptor antagonist infusions did not impair retention when administered into the BLA 3 h after training, the retention impairment selectively was due to time-dependent influences on memory consolidation. Furthermore, because immediate posttraining infusions of [9-41]-alpha-helical CRH into the adjacent central nucleus of the annygdala (CEA) were ineffective, the effect selectively involved the BLA. Immunocytochemistry showed that the aversive training stimulus of a single, brief footshock increased CRH levels in the CEA. These findings indicate that activation of CRH receptors in the BILA, likely by training-induced release of endogenous peptide originating from the CEA, participates in mediating stress effects on memory consolidation.
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