Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 99, Issue 21, Pages 13693-13698Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.212392399
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Funding
- NIAID NIH HHS [R01 AI023548, AI 23548, R01 AI013509, R37 AI013509, AI 13509] Funding Source: Medline
- NIGMS NIH HHS [R01 GM045751, GM 45751] Funding Source: Medline
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The 3' lg heavy chain locus (Igh) regulatory region is the most downstream known element of the murine lgh gene cluster. We report here that the nearest non-Igh genes-Crip, Crp2, and Mta1-are located approximate to70 kb further downstream and are beyond the end of the domain of lgh transcriptional regulation. We have localized an origin of replication in MEL cells to a 3-kb segment located between the 3' Igh regulatory region and Crip. Sequences downstream of this origin are replicated by forks that move in both directions. Sequences upstream of this origin (Igh-C, -D, and -J) are replicated in a single direction through a 500-kb segment in which no active bidirectional origins can be detected. We propose that this origin may lie at or near the end of the Igh regulation domain.
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