4.7 Article

Total synthesis of anhydrolycorinone utilizing sequential intramolecular Diels-Alder reactions of a 1,3,4-oxadiazole

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 67, Issue 21, Pages 7361-7364

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo020437k

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Funding

  1. NCI NIH HHS [CA42056] Funding Source: Medline

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A convergent total synthesis of anhydrolycorinone is detailed, enlisting sequential intramolecular Diels-Alder reactions of a suitably substituted 2-amino-1,3,4-oxadiazole defining a novel oxadiazole -> furan -> benzene Diels-Alder strategy.

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