4.5 Article

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: Polar functionality and its effect on anti-HIV-1 activity

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 12, Issue 20, Pages 2997-3000

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(02)00605-4

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Incorporation of acidic functional groups into a lead CCR5 antagonist identified from a targeted combinatorial library resulted in compounds with enhanced anti-HIV-1 activity and attenuated L-type calcium channel affinity. (C) 2002 Elsevier Science Ltd. All rights reserved.

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