Journal
ONCOGENE
Volume 21, Issue 49, Pages 7507-7513Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1205903
Keywords
genetic instability; chromosome segregation; HPV 16 E6
Funding
- NCI NIH HHS [CA 42792] Funding Source: Medline
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Expression of the human papillomavirus type 16 E6 and E7 oncogenes initiates and maintains abnormal cell replication, by interacting with the p53 and retinoblastoma (Rb) gene products. Subsequent changes in host cell gene expression, as a consequence of genetic instability, can result in progression to invasive carcinoma. In addition to previously described effects of these viral oncogenes on centrosome synthesis, primarily associated with the expression of E7, the results described herein demonstrate that the E6 oncogene can induce premature chromosome segregation in human cells.
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