Journal
BRAIN RESEARCH
Volume 953, Issue 1-2, Pages 12-16Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(02)03219-5
Keywords
angiogenesis; cerebral cortex; Duchenne muscular distrophy; endothelial cells; VEGF; VEGFR-2
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Recent data have demonstrated that vascular endothelial growth factor (VEGF) is expressed by subsets of neurons, coincident with angiogenesis within its developing cerebral cortex. In this study, with the aim of elucidating the mechanisms of vascular involvement during brain impairment in Duchenne muscular distrophy (DMD), we have correlated the vascular density with VEGF and VEGF receptor-2 (VEGFR-2) expression in the brain cortex of normal and mdx mouse, an animal model with a genetic defect in a region homologous with the human DMD gene. Results showed that in mdx mouse, tissue area occupied by microvessels positive to factor VIII related antigen and VEGFR-2 increased in parallel to the tissue area occupied by neurons positive to VEGF. Our data suggest that increased vascularity in the brain of mdx mouse may be due, at least in part, to proliferation of endothelial cells in response to VEGF secreted by neuronal cells. (C) 2002 Elsevier Science B.V. All rights reserved.
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