Journal
FEBS LETTERS
Volume 531, Issue 1, Pages 103-108Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(02)03404-X
Keywords
CD34; PECAM-1; EDG; G-protein coupled receptor; cerebral cortex; mesencephalon; LPA; S1P; 1pB
Funding
- NIGMS NIH HHS [F31 GM18927] Funding Source: Medline
- NIMH NIH HHS [K02MH01723] Funding Source: Medline
Ask authors/readers for more resources
In a comparison of embryonic brain expression patterns of lysophosphatidic acid and sphingosine 1-phosphate receptor genes (lpa(1-3) and s1p(1-5), respectively), transcripts detected by Northern blot were subsequently localized using in situ hybridization. We found striking s1p(1) expression adjacent to several ventricles. Near the lateral ventricle, s1p(1) expression was temporally and spatially coincident with neurogenesis and overlapped with lpa(1) in the neocortical area. We also observed a widespread diffuse pattern for lpa(2-3) and a scattered punctate pattern for s1p(1-3). The punctate pattern colocalized with vascular endothelial markers. Together, these results suggest that s1p(1) influences neurogenesis and s1p(1-3) influence angiogenesis in the developing brain. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available