Journal
NEUROSCIENCE LETTERS
Volume 332, Issue 2, Pages 119-122Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(02)00932-1
Keywords
intracerebroventricular; scorpion venom; Tityus serrulatus; neuroprotection; toxin; edema; neurogenic
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The aim of this study was to evaluate the ability of phenobarbital to block the lung edema observed after intracerebroventricular (icv) injections of tityustoxin (TsTX); a toxic fraction of the Tityus serrulatus venom. We injected 1.74 mug icv (1.0 mul) of TsTX in Wistar rats pre-treated with 0.1 ml intramuscular injections of sterile saline or phenobarbital (60 or 170 mg/kg body weight). After the experiments the lungs were harvested and the pulmonary index (PI = lung/body weight x 100) calculated. The animals pre-treated with saline developed severe lung edema (PI = 1.8 +/- 0.2) after TsTX icv injection whereas those that received 170 mg/kg of phenobarbital presented no lung edema (PI = 0.71 +/- 0.02). Our results suggest that the lung edema induced by TsTX is of neurogenic nature and that 170 mg/kg of phenobarbital blocks TsTX induced lung edema. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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