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Epigenetic consequences of nucleosome dynamics

Journal

CELL
Volume 111, Issue 3, Pages 281-284

Publisher

CELL PRESS
DOI: 10.1016/S0092-8674(02)01081-4

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Current models for epigenetic gene silencing envision a static relationship between histone modifications and transcription. However, evidence for nucleosome mobility and replacement favors a dynamic model that may explain phenomena ranging from variegation to the neural restriction of Rett syndrome.

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