Journal
JOURNAL OF DIABETES AND ITS COMPLICATIONS
Volume 16, Issue 6, Pages 395-400Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S1056-8727(02)00164-2
Keywords
aminoguanidine; probucol; albumin; tamm-horsfall protein; urine; nephropathy; diabetes; rat
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We investigated whether aminoguanidine (AG), an inhibitor of advanced glycated end product formation, or probucol (PB), a free radical scavenger, could influence signs of glomerular and distal tubular function and morphological changes in kidneys of male Wistar rats after 6 months of streptozoein (STZ)-induced diabetes. Diabetic rats had a higher kidney weight/body weight ratio (P < .001), but neither AG nor PB influenced the increased ratio. Diabetes caused an increased urinary albumin excretion (P < .05), which was normalized by AG, but further exaggerated by PB (P < .001). Diabetes also caused an increase in the urinary excretion of Tamm-Horsfall protein (P < .001). Both AG and PB attenuated this increase (P < .05 for both). A few glomeruli displayed focal thickening of varying degrees. Silver staining disclosed the glomerulopathy to be intercapillary glomerulosclerosis. Rats on PB-enriched diet displayed less pronounced changes than untreated rats (P < .01), while AG had no effect. The results suggest that oxidative stress could be involved in the development of diabetic nephropathy. (C) 2002 Elsevier Science Inc. All rights reserved.
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