Journal
PSYCHOPHYSIOLOGY
Volume 39, Issue 6, Pages 861-864Publisher
WILEY
DOI: 10.1111/1469-8986.3960861
Keywords
major depression; vagus nerve; heart rate variability; respiratory sinus arrhythmia; polyvagal theory; treatment response
Funding
- NCCIH NIH HHS [R01 AT000001-04, 1R01AT00001] Funding Source: Medline
- NCRR NIH HHS [1R21RR09492] Funding Source: Medline
- NIMH NIH HHS [1R01MH56965] Funding Source: Medline
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Increased vagal tone has been associated with treatment Success using pharmacological agents and cognitive-behavioral treatment in major depression. but not using electroconvulsive therapy. The present study investigated whether increases in vagal tone would be associated with favorable treatment response with nonpharmacological treatment. At baseline and follows in,, treatment, 16 subjects were administered the Hamilton Rating Scale for Depression (HRSD) followed by electrocardiographic recording. Those with little change in vagal tone from before to after treatment showed minimal reduction in HRSD score (-4.8): those with larger vagal tone change showed a large decrease in HRSD score (-14.8). Changes in vagal tone are thus related to favorable treatment response in depression, and do not represent anticholinergic pharmacological effects, Future work manipulating vagal tone might prove informative in leasing apart the causal role of vagal tone and depression.
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