Journal
JOURNAL OF VIROLOGY
Volume 76, Issue 21, Pages 11148-11154Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.76.21.11148-11154.2002
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A direct comparison of the inhibitory effects of alpha, beta, and gamma interferons (IFNs) on replication of a hepatitis C virus subgenomic replicon in a hepatoma cell line revealed similarities in antiviral potency. However, alternate IFN-induced antiviral mechanisms were suggested following observations of striking differences between IFN-gamma and IFN-alpha/beta with respect to strength and durability of the antiviral response and the magnitude and pattern of IFN-mediated gene expression.
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