Journal
CHEMICAL SOCIETY REVIEWS
Volume 31, Issue 6, Pages 365-370Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b205280f
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Kinetic resolution of racemic mixtures is a well-established methodology for the preparation of optically active compounds. However, excellent enantioselectivities are required to obtain them in enantiopure form, due to the decrease in ee when conversion values are close to 50%. To overcome this limitation, a parallel (asymmetric) reaction can remove the disfavored enantiomer. In this review, several examples of this strategy showing its wide range of applicability are described, as well as their mathematical treatment and some new applications in combinatorial chemistry.
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