Journal
ANNALS OF BIOMEDICAL ENGINEERING
Volume 30, Issue 10, Pages 1251-1261Publisher
BIOMEDICAL ENGINEERING SOC AMER INST PHYSICS
DOI: 10.1114/1.1529196
Keywords
bone healing; bone formation; distraction osteogenesis; therapeutic pulsed ultrasound
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Funding
- NCRR NIH HHS [NCRR 14250] Funding Source: Medline
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This study evaluated the effect of pulsed ultrasound on tissue repair and bone growth during mandibular osteodistraction. Twenty-one rabbits were divided into three groups of 7. The distraction started 72 h after surgically severing both sides of the mandible and proceeded at a rate of 1.5 mm/12 h for 5 days. Group 1 received pulsed ultrasound (nominally 200 mus pulse of 1.5 MHz at a 1.1 kHz pulse repetition frequency, 30 mW/cm(2)) for 20 min on both sides of the mandible every other day (alternating sides). Group 2 received the same pulsed ultrasound treatment on one side of the mandible every day for 20 min. Group 3 did not receive any ultrasound treatment. Bone formation at the distraction site was assessed by photo-densitometry on head radiographs, a vibratory coherence test across the distraction site, a postmortem three-point bending mechanical stiffness test, and a postmortem histological examination. Statistical analyses performed using analysis of variance revealed that pulsed ultrasound enhanced bone formation at the distraction site with a high level of significance when assessed by the increase in new bone photodensity (p = 0.001), vibratory coherence (p = 0.001), mechanical stiffness (p = 0.003), and qualitative histological studies, especially when the pulsed ultrasound treatment was directly applied daily. (C) 2002 Biomedical Engineering Society.
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