Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 132, Issue 1-2, Pages 18-24Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(02)00279-5
Keywords
nitric oxide; nitric oxide synthase; CNS; multiple sclerosis; sesquiterpene lactones; feverfew (Tanacetum parthenium)
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Nitric oxide (NO) has been implicated in the etiopathology of central nervous system (CNS) diseases such as multiple sclerosis (NIS). Inhibition of NO synthesis has been proposed to be a possible mechanism of action of relevance in the treatment of multiple sclerosis and migraine. Here, we investigated the effect of parthenolide on inducible NO synthase (iNOS) synthesis and NO release using primary rat microglia. We found parthenolide to be an inhibitor of iNOS/NO synthesis. Investigating the molecular mechanisms by which parthenolide prevents iNOS/NO synthesis, we found that parthenolide inhibits the activation of p42/44 mitogen-activated protein kinase (MAPK), but not IkBalpha (IkappaBalpha) degradation or nuclear factor-kappaB (NF-kappaB) p65 activation. The data suggest that parthenolide might have a potential in the treatment of CNS diseases where NO is part of the pathophysiology. (C) 2002 Elsevier Science B.V. All rights reserved.
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