Journal
MICROBES AND INFECTION
Volume 4, Issue 13, Pages 1335-1343Publisher
EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S1286-4579(02)00011-4
Keywords
listeria monocytogenes; intracellular signaling; macrophage; phospholipase C; protein kinase C
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Macrophages are critical for control of Listeria monocytogenes infections; accordingly, the interactions of L. monocytogenes with these cells have been intensively studied. It has become apparent that this facultative intracellular pathogen interacts with macrophages both prior to entry and during the intracellular phase. This review covers recent work on signaling induced in macrophages by L. monocytogenes, especially intracellular signals induced by secreted proteins including listeriolysin O and two distinct phospholipases C. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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