Journal
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
Volume 26, Issue 6, Pages 922-926Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00004728-200211000-00011
Keywords
ameloblastonia; mandible; odontogenic cyst; computed tomography; neovascularization
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Purpose: The purpose of this study was to assess whether the enhancement characteristics of dynamic multislice helical CT (MS-CT) could help in the differential diagnosis of ameloblastomas and odontogenic keratocysts. The correlation between enhancement characteristics and immunohistochemical findings, especially with regard to angiogenesis, was also evaluated. Method: Dynamic MS-CT was performed in 13 consecutive patients (8 anleloblastoma cases and 5 odontogenic keratocyst cases). The percentage of density increase (Enh%) was measured in dynamic MS-CT images taken during the arterial phase, and microvessel density (MVD) was analyzed using immunohistochemical study with anti-CD31 antibody. The Mann-Whitney U test was used to evaluate the significance of the Enh% or the MVD values between lesion subtype, and the Spearman correlation coefficient was used to evaluate the correlation between the Enh% and the MVD in ameloblastomas and odontogenic keratocysts. Results: The Enh% in ameloblastomas was significantly higher than that of odontogenic keratocysts (P < 0.005). The MVD of ameloblastomas was also significantly higher than that of odontogenic keratocysts (P < 0.005). The Enh%(values for ameloblastomas and odontogenic keratocysts were positively correlated with the respective MVD values (r = 0.92, P less than or equal to 0.000). Conclusion: Dynamic MS-CT is useful tool for differentiating between ameloblastomas and odontogenic keratocysts on the basis of the contrast enhancement Values Of intratumoral vascularities during the arterial phase. Furthermore, the Enh% obtained by dynamic MS-CT is correlated with the MVD in ameloblastomas and odontogenic keratocysts.
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