Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 30, Issue -, Pages 1091-1095Publisher
PORTLAND PRESS
DOI: 10.1042/bst0301091
Keywords
cholesterol; fatty acids; lipogenesis; transcription factor
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Sterol regulatory element-binding proteins (SREBPs) are a family of transcription factors that regulate lipid homoeostasis. Three SREBP isoforms control the expression of more than 30 genes required for the biosynthesis of cholesterol, fatty acids, triacylglycerols and phospholipids. The unique regulation and activation properties of each SREBP isoform facilitates the co-ordinate regulation of all essential lipid building blocks required for cell membranes as well as for very-low-density lipoprotein formation in hepatocytes.
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