Journal
ELECTROPHORESIS
Volume 23, Issue 22-23, Pages 3934-3953Publisher
WILEY
DOI: 10.1002/elps.200290011
Keywords
capillary electrochromatography; column technology; monolith; porous polymer; review
Funding
- NIGMS NIH HHS [GM-48364] Funding Source: Medline
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This review summarizes the contributions of a number of groups working in the rapidly growing area of monolithic columns for capillary electrochromatography (CEC), with a focus on those prepared from synthetic polymers. Monoliths have quickly become a well-established stationary phase format in the field of CEC. The simplicity of their in situ preparation method as well as the good control over their porous properties and surface chemistries make the monolithic separation media an attractive alternative to capillary columns packed with particulate materials. A wide variety of approaches as well as materials used for the preparation of the monolithic stationary phases are detailed. Their excellent chromatographic performance is demonstrated by numerous separations of different analytes.
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