Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 3, Issue 11, Pages 848-858Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm950
Keywords
-
Categories
Ask authors/readers for more resources
Intermediate filament (IF) proteins are the building blocks of cytoskeletal filaments, the main function of which is to maintain cell shape and integrity. The lamins are thought to be the evolutionary progenitors of IF proteins and they have profound influences on both nuclear structure and function. These influences require the lamins to have dynamic properties and dual identities - as building blocks and transcriptional regulators. Which one of these identities underlies a myriad of genetic diseases is a topic of intense debate.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available