Journal
JOURNAL OF VIROLOGY
Volume 76, Issue 22, Pages 11744-11747Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.76.22.11744-11747.2002
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The recovery of recombinant influenza A virus entirely from cDNA was recently described (9, 19). We adapted the technique for engineering influenza B virus and generated a mutant bearing an amino acid change E116G in the viral neuraminidase which was resistant in vitro to the neuraminidase inhibitor zanamivir. The method also facilitates rapid isolation of single-gene reassortants suitable as vaccine seeds and will aid further investigations of unique features of influenza B virus.
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