Journal
ACCOUNTS OF CHEMICAL RESEARCH
Volume 35, Issue 11, Pages 936-943Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ar000183u
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- NIGMS NIH HHS [GM52956] Funding Source: Medline
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DNA is not only a carrier of genetic information, but it is also a versatile supramolecular scaffold, arranging smaller organic structures into predesigned geometries. Herein are discussed molecular strategies in which the natural DNA bases on the sugar-phosphate backbone are replaced by other molecules. Some of the base replacements under study include fluorophores, ligands for metals, helix stabilizers, and DNA base shape mimics.
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