Journal
TRENDS IN MOLECULAR MEDICINE
Volume 8, Issue 11, Pages 537-542Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1471-4914(02)02413-9
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Several human pathogens exhibit a restricted host-tropism, relying on the species-specific interaction of microbial ligand(s) with host receptor(s). This specificity accounts for some of the difficulties in modeling human infections in animals. The discovery of L. monocytogenes host-specificity and elucidation of the underlying mechanism has led to the generation of transgenic mice expressing one of its human receptors, E-cadherin. This model is presented here as a paradigm of a genetically-modified-animal model for studying a human infectious disease.
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