Journal
JOURNAL OF VIROLOGY
Volume 76, Issue 22, Pages 11770-11774Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.76.22.11770-11774.2002
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Funding
- NCI NIH HHS [CA54557] Funding Source: Medline
- NIDDK NIH HHS [T32DK07664, T32 DK007664] Funding Source: Medline
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Humans chronically infected with hepatitis B virus (HBV) are at further risk of liver cancer upon exposure to dietary aflatoxin B1 (AFB1), a carcinogenic product of the mold Aspergillus flavus. For the present study, we utilized double-transgenic mice (ATX mice) that express the HBV X protein (HBx) and possess a bacteriophage lambda transgene to evaluate the in vivo effect of HBx expression on AFB1-induced DNA mutations. The expression of HBx correlated with a 24% increase in mutation frequency overall and an approximately twofold increase in the incidence of G/C-to-T/A transversion mutations following AFB1 exposure. These results are consistent with a model in which expression of HBx during chronic HBV infection may contribute to the development of hepatocellular carcinoma following exposure to environmental carcinogens.
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