4.5 Article

BCR-ABL insufficiency for the transformation of human stem cells into CML

Journal

MEDICAL HYPOTHESES
Volume 59, Issue 5, Pages 588-589

Publisher

CHURCHILL LIVINGSTONE
DOI: 10.1016/S0306-9877(02)00220-7

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On the basis of numerical and kinetic data, the paper argues against the tenet that BCR-Abl is sufficient for transforming into Chronic Myelogenous leukemia a human hemopoietic stem cell, regardless of degree of pluripotency. (C) 2002 Published by Elsevier Science Ltd.

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