Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 132, Issue 1-2, Pages 140-146Publisher
ELSEVIER
DOI: 10.1016/S0165-5728(02)00324-7
Keywords
iron overload; Cryptocoecus neoformans; meningoencephalitis; immune response
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This study was aimed at investigating the effects of iron overload on the onset and outcome of cerebral cryptococcosis. To this purpose, iron dextran-administered mice were intracerebrally challenged with virulent melanogenic and avirulent non-melanogenic strains of Cryptococcus neoformans. The results shown here provide the first evidence that iron overload exacerbates the outcome of cryptococcal meningoencephalitis, irrespective of the fungal strain employed; pathogen colonization of the brain is facilitated, local cytokine response is delayed and/or prevented. (C) 2002 Elsevier Science B.V All rights reserved.
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