Journal
AMERICAN HEART JOURNAL
Volume 144, Issue 5, Pages 753-759Publisher
MOSBY-ELSEVIER
DOI: 10.1067/mhj.2002.124865
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Background A number of studies have used B-mode ultrasound to measure carotid intimal-medial thickness as an indicator of the severity of carotid atherosclerosis. Methods We reviewed the available data on carotid intimal-medial thickness in defining severity of atherosclerosis, with the use of high-quality studies that addressed clinical end points. Results Data from multiple studies demonstrate a high degree of reproducibility in measurements of intimal-medial thickness. A number of agents that include 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, angiotensin-converting enzyme inhibitors, and insulin sensitizers reduce carotid intimal-medial thickness and cardiovascular events, such as myocardial infarction and stroke. Conclusions in this review article, various methods, of measuring carotid intimal-medial thickness are examined and critiqued. In addition, the effects of various lifestyle modifications and therapeutic agents on intimal-medial thickness and cardiovascular end points are evaluated.
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