Journal
CHEST
Volume 122, Issue 5, Pages 1858-1860Publisher
AMER COLL CHEST PHYSICIANS
DOI: 10.1378/chest.122.5.1858
Keywords
drug injury; etanercept; granulomatous inflammation; inflammatory lung disease; rheumatoid arthritis
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Etanercept is the first anticytokine drug approved to treat rheumatoid arthritis. Side effects are infrequent, the most common being local skin reactions, headaches, and upper respiratory tract symptoms. We report the first case of lung injury that occurred while receiving this agent. Biopsy specimens of lung and skin lesions demonstrated noneaseating granulomas associated with a microscopic particulate. Withdrawal of etanercept achieved clinical stabilization, and the addition of prednisone resulted in rapid improvement.
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