Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 6, Issue 6, Pages 817-818Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op0255478
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A simple, efficient, green, and cost-effective procedure has been developed for the synthesis of dihydropyrimidinones by a solvent-free and catalyst-free Biginelli's condensation of 1,3- dicarbonyl compound, aldehyde, and urea. This approach of direct reaction in neat without solvent and catalyst shows a new direction in green synthesis.
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