Journal
BRAIN AND COGNITION
Volume 50, Issue 2, Pages 194-206Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S0278-2626(02)00503-1
Keywords
neuropsychological performance; MSA; sOPCA; dOPCA
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Funding
- NIA NIH HHS [AG 07378, AG 08671] Funding Source: Medline
- NINDS NIH HHS [NS 15655] Funding Source: Medline
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Although neuropsychological symptoms are associated with multiple system atrophy (MSA), sporadic olivopontocerebellar atrophy (sOPCA), and dominantly inherited olivopontocerebellar atrophy (dOPCA), the differences between these groups have not been explored. We compared 28 MSA patients on psychiatric rating scales and neuropsychological measures to 67 sOPCA patients, 42 dOPCA patients, and 30 normal controls. Patients with dOPCA, sOPCA, and MSA all exhibited significant deficits on motor-related tasks, as well as relatively mild deficits in cognitive functioning. Patients with MSA had greater neuropsychological dysfunction, particularly in memory and other higher order cognitive processes, than patients with either sOPCA or dOPCA. (C) 2002 Elsevier Science (USA). All rights reserved.
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