Journal
GLIA
Volume 40, Issue 2, Pages 260-269Publisher
WILEY
DOI: 10.1002/glia.10153
Keywords
microglia; complement; amyloid beta peptide
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Funding
- NIA NIH HHS [AGO7367] Funding Source: Medline
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There is now abundant evidence that brain microglia, when activated, have the lineage, receptors, and synthetic capacity to participate in both potentially neurotoxic inflammatory responses and potentially beneficial phagocytic responses. Amyloid beta peptide (Abeta) forms highly insoluble, beta-pleated aggregates that are widely deposited in the Alzheimer's disease (AD) cortex and limbic system. Aggregated Abeta also activates the classical and alternative complement cascades. These properties make Abeta an excellent target for microglial phagocytosis, a view supported by multiple reports, through well established mechanisms of phagocyte clearance. (C) 2002 Wiley-Liss, Inc.
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