Journal
NATURE REVIEWS IMMUNOLOGY
Volume 2, Issue 11, Pages 845-858Publisher
NATURE RESEARCH
DOI: 10.1038/nri933
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Established models of T-helper-2-cell dominance in BALB/c mice infected with Leishmania major - involving the early production of interleukin-4 by a small subset of Leishmania-specific CD4(+) T cells - have been refined by accumulating evidence that this response is not sufficient and, under some circumstances, not required to promote susceptibility. In addition, more recent studies in L. major-resistant mice have revealed complexities in the mechanisms responsible for acquired immunity, which necessitate the redesign of vaccines against Leishmania and other pathogens that require sustained cell-mediated immune responses.
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