Journal
QUIMICA NOVA
Volume 25, Issue 6B, Pages 1181-1185Publisher
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0100-40422002000700019
Keywords
liposome; vesicle; drug delivery
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Efficient drug delivery systems are as important as drug themselves. A powerful drug unable to reach the target cell is useless in practice. Ehrlich's Magic Bullet was the first carrier system to be proposed. The evolution in this domain has been quite slow as the natural mechanisms of mammals against foreign products are hard to overcome. However, lipid-based systems (liposomes and related vesicles) have attained reasonable success. The basic preparations and structural features of liposomes and related vesicles as well as their applications are addressed from the chemist's and biochemist's point of view.
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