Journal
IMMUNITY
Volume 17, Issue 5, Pages 605-615Publisher
CELL PRESS
DOI: 10.1016/S1074-7613(02)00456-9
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Funding
- NCI NIH HHS [CA-46934] Funding Source: Medline
- NIAID NIH HHS [AI-18785, AI-22295, AI-17134, AI-52225] Funding Source: Medline
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An examination of differences in gene expression between memory and naive phenotype T cells revealed elevated levels of mRNA for several chemokines, especially RANTES, in memory phenotype T cells. Although RANTES mRNA is spliced and cytoplasmic, these cells do not contain or secrete significant amounts of RANTES protein without TCR stimulation. This secretion is independent of transcription, but requires translation. In vivo, CD8+ memory T cells proliferate continuously and slowly in response to IL-15; however, IL-15 does not stimulate RANTES secretion. These results show that memory phenotype CD8+ T cells use preexisting mRNA to produce and secrete RANTES rapidly following TCR stimulation. Such storage of preformed mRNAs for important inflammatory mediators may contribute to the speed of secondary immune responses.
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