Journal
OPHTHALMIC RESEARCH
Volume 34, Issue 6, Pages 331-337Publisher
KARGER
DOI: 10.1159/000067043
Keywords
nipradilol; nitric oxide; retinal ischemia/reperfusion; electroretinogram; glaucoma
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The purpose of this study was to investigate whether nipradilol, a beta-blocker having both vasodilating and a,blocking activities, can protect retinal cells from the injury induced by ischemia and reperfusion. Rats were anesthetized and, after an intravitreal injection of nipradilol, the intraocular pressure was raised for 45 min to induce retinal ischemia and reperfusion. Before, and 3 and 7 days after the ischemia, electroretinograms were recorded. After the ischemia, the mean amplitude of the b-waves in rats receiving 5 mul of 1.0 x 10(-6) M nipradilol was significantly larger than of controls (injected with phosphate-buffered saline). Histologically, the reduction in the number of retinal ganglion cells (1.0 x 10(-6) M), and the thickness of the inner and outer plexiform layers and the inner nuclear layer (1.0 x 10(-6), 10(-7) and 10(-8) M) was suppressed by nipradilol. These results indicate that nipradilol protected the retina against retinal ischemia and reperfusion and should be considered for therapeutic use in cases of transient retinal ischemia. Copyright (C) 2002 S. Karger AG, Basel.
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