Journal
CELL CYCLE
Volume 1, Issue 6, Pages 391-393Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.1.6.262
Keywords
p27; p21; Apoptosis; Tumor suppressor
Categories
Ask authors/readers for more resources
By causing cytoplasmic mislocation of p27 and p21, the Akt oncogenic kinase functionally inactivates these nuclear tumor suppressor proteins. Is cytoplasmic localization of p27 and p21 simply equivalent to loss of their function or are new functions acquired in the cytoplasm? Indeed, several lines of evidence suggest that cytoplasmic p27 and p21 may be oncoproteins with antiapoptotic activities.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available