Journal
YEAST
Volume 19, Issue 15, Pages 1323-1333Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/yea.919
Keywords
chromatid cohesion; two-hybrid; Lin1p; splicing
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Proteins involved in chromosome segregation during mitosis are likely to participate in other cell cycle-coordinated processes. Using a two-hybrid screen we identified a novel nuclear protein, Lin1, interacting with Irr1p/Scc3p, a component of the cohesin complex. The second round of two-hybrid assay with Lin1p as the bait resulted in the identification of six proteins: Prp8, Slx5, Siz2, Wss1, Rfc1 and YIL149w. These proteins have previously been shown to participate in mRNA splicing, DNA replication, chromosome condensation, chromatid separation and alternative cohesion. We propose that Lin1p may constitute a link among these processes. Copyright (C) 2002 John Wiley Sons, Ltd.
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