Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 27, Issue 11, Pages 552-558Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(02)02177-1
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The toxic products of the anaerobic bacteria Clostridium botulinum, Clostridium butyricum, Clostridium balrati and Clostridium tetani are the causative agents of botulism and tetanus. The ability of botulinum neurotoxins to disrupt neurotransmission, often for prolonged periods, has been exploited for use in several medical applications and the toxins, as licensed pharmaceutical products, now represent the therapeutics of choice for the treatment for several neuromuscular conditions. Research into the structures and activities of botulinum and tetanus toxins has revealed features of these proteins that might be useful in the design of improved vaccines, effective inhibitors and novel biopharmaceuticals. Here, we discuss the relationships between structure, mechanism of action and therapeutic use.
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