Journal
SCIENCE
Volume 298, Issue 5595, Pages 1029-1033Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1074360
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Funding
- NHLBI NIH HHS [NIHR01HL54598] Funding Source: Medline
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Ion channels on the mitochondrial inner membrane influence cell function in specific ways that can be detrimental or beneficial to cell survival. At least one type of potassium (K+) channel, the mitochondrial adenosine triphosphate sensitive K+ channel (mitoK(ATP)), is an important effector of protection against necrotic and apoptotic cell injury after ischemia. Here another channel with properties similar to the surface membrane calcium-activated K+ channel was found on the mitochondrial inner membrane (mitoK(Ca)) of guinea pig ventricular cells. MitoK(Ca) significantly contributed to mitochondrial K+ uptake of the myocyte, and an opener of mitoK(Ca) protected hearts against infarction.
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