Journal
CELL CALCIUM
Volume 32, Issue 5-6, Pages 279-305Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0143416002001847
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Intracellular Ca2+-transport ATPases exert a pivotal role in the endoplasmic reticulum and in the compartments of the cellular secretory pathway by maintaining a sufficiently high lumenal Ca2+ (and Mn2+) concentration in these compartments required for an impressive number of vastly different cell functions. At the same time this lumenal Ca2+ represents a store of releasable activator Ca2+ controlling an equally impressive number of cytosolic functions. This review mainly focuses on the different Ca2+-transport ATPases found in the intracellular compartments of mainly animal non-muscle cells: the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) pumps. Although it is not our intention to treat the ATPases of the specialized sarcoplasmic reticulum in depth, we can hardly ignore the SERCA1 pump of fast-twitch skeletal muscle since its structure and function is by far the best understood and it can serve as a guide to understand the other members of the family. In a second part of this review we describe the relatively novel family of secretory pathway Ca2+/Mn2+ ATPases (SPCA), which in eukaryotic cells are primarily found in the Golgi compartment. (C) 2002 Elsevier Science Ltd. All rights reserved.
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