Journal
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
Volume 75, Issue 11, Pages 2423-2432Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/bcsj.75.2423
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Twelve new amino acid derivatives/Zn(II) complexes were prepared by the reactions of ZnSO4 and nine tetradentate ligands, Gly, Ala, Val, Leu, Ser and His derivatives and three pentadentate ligands, Asp and His derivatives. The X-ray structure analysis of [Zn-3(N-pyridylmethyl-His)(3)(H2O)(2)](ClO4)(3)(.)2H(2)O revealed the formation of a trinuclear complex, in which three tetradentate ligands and two water molecules coordinate to three Zn(II), but the complex in an aqueous solution is present as a monomeric complex ion. Several Zn(II) complexes were found to have in vitro insulinomimetic activity which was estimated by the inhibition of free fatty acid release in isolated rat adipocytes treated with epinephrine. It was revealed that the insulinomimetic activities of Zn(II) complexes with the stability constants (log beta) less than 11 were higher than that of VOSO4 and were comparable to that of ZnSO4 as positive controls except in the cases of two complexes with Gly derivatives, Zn(N,N-dipyridylmethyl-Gly)(+) and Zn(N,N'-trimethylene-bis-Gly).
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