Journal
CHEMICAL SOCIETY REVIEWS
Volume 31, Issue 6, Pages 335-341Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b201097f
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- NIGMS NIH HHS [GM65500-01] Funding Source: Medline
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Selective incorporation of unnatural amino acids into proteins is a powerful tool for illuminating the principles of protein design. In particular, fluorinated amino acids have recently emerged as valuable building blocks for designing hyperstable protein folds, as well as directing highly specific protein-protein interactions. We review the collagen mimetic and coiled coil peptide systems that exemplify generalizable paradigms for future design. The unique electronic and phase properties of fluorocarbons are discussed, and protein synthesis using unnatural amino acids is briefly reviewed.
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