Journal
JOURNAL OF APPLIED PHYSIOLOGY
Volume 93, Issue 5, Pages 1779-1785Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00210.2002
Keywords
respiratory sensation; load compensation; psychophysics; inspiratory load
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Funding
- NHLBI NIH HHS [HL-47892] Funding Source: Medline
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The afferent pathways mediating respiratory load perception are still largely unknown. To assess the role of lung vagal afferents in respiratory sensation, detection of inspiratory resistive loads was compared between 10 double-lung transplant (DLT) recipients with normal lung function and 12 healthy control (Nor) subjects. Despite a similar unloaded and loaded breathing pattern, the DLT group had a significantly higher detection threshold (2.91 +/- 0.5 vs. 1.55 +/- 0.3 cmH(2)O.l(-1).s) and Weber fraction (0.50 +/- 0.1 vs. 0.30 +/- 0.1) compared with the Nor group. These results suggest that inspiratory resistive load detection occurs in the absence of vagal afferent feedback from the lung but that lung vagal afferents contribute to inspiratory resistive load detection response in humans. Lung vagal afferents are not essential to the regulation of resting breathing and load compensation responses.
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