Journal
NEUROPSYCHOPHARMACOLOGY
Volume 27, Issue 5, Pages 792-799Publisher
NATURE PUBLISHING GROUP
DOI: 10.1016/S0893-133X(02)00352-4
Keywords
neuroimaging; magnetic resonance imaging; mood disorders; affective disorders; bipolar disorder; unipolar disorder; depression
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Funding
- NIMH NIH HHS [MH 01736, MH 30915, MH 29618] Funding Source: Medline
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This study attempted to replicate previous findings of decreased gray matter content in the subgenual prefrontal cortex (SGPFC) in mood disorder patients. Eighteen DSM-IV unipolar patients, 27 DSM-IV bipolar patients, and 38 healthy controls were studied. A 1.5T GE Signa Imaging System with Signa 5.4.3 software was used. The semi-automated software MedX (Sensor Systems, Sterling, VA) was utilized for the anatomical measures of SGPFC volumes. There were no significant differences in SGPFC volumes in familial and non-familial unipolar and bipolar patients compared with healthy controls, nor between drug-free and lithium-treated bipolar patients (ANOVA, p >.05). In vivo abnormalities in the volumes of SGPFC were not identified in mildly depressed or euthymic unipolar or bipolar mood disorder outpatients, either familial or non-familial. (C) 2002 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.
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