Journal
SCHIZOPHRENIA RESEARCH
Volume 58, Issue 1, Pages 75-81Publisher
ELSEVIER
DOI: 10.1016/S0920-9964(02)00201-3
Keywords
prefrontal cortex; Golgi; schizophrenia; dendrites; morphology; postmortem
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Funding
- NIGMS NIH HHS [5S06GM08225-16] Funding Source: Medline
- NIMH NIH HHS [MH/NS31862] Funding Source: Medline
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A variety of lines of converging evidence implicates the prefrontal cortex (PFC) in schizophrenia. Previous neuroanatomical studies have shown schizophrenia-associated changes in neuron density, soma size and spine number. We recently demonstrated a schizophrenia-associated decrease in microtubule-associated protein 2 (MAP2) immunostaining in laminae III and V of medial prefrontal area 32 and interpreted that finding as suggestive of a loss of dendritic material. We now present data from medial prefrontal area 32 of II schizophrenics and II comparison subjects. In Golgi-stained material, we describe a significant decrease in the number of both primary (29%) and secondary (46%) basilar dendrites on pyramidal neurons in layer V. Similarly, in layer III there was also a decrease in both primary (17%) and secondary (15%) basilar dendrites. These findings suggest a decrease in synaptic surface area which could lead to aberrant information processing. (C) 2002 Elsevier Science B.V. All rights reserved.
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