Journal
BRITISH JOURNAL OF CANCER
Volume 87, Issue 10, Pages 1057-1065Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6600625
Keywords
tumour angiogenesis; genetic polymorphism(s)
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Angiogenesis plays a crucial role in the development, growth and spread of solid tumours. Pro- and anti-angiogenic factors are abnormally expressed in tumours, influencing tumour angiogenesis, growth and progression. Polymorphisms in genes encoding angiogenic factors or their receptors may alter protein expression and/or activity. This article reviews the literature to determine the possible role of angiogenesis-related polymorphisms in cancer. Further research studies in this potentially crucial area of tumour biology are proposed. (C) 2002 Cancer Research UK.
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