Journal
FEBS LETTERS
Volume 531, Issue 2, Pages 115-121Publisher
WILEY
DOI: 10.1016/S0014-5793(02)03399-9
Keywords
glycosylation; polypeptide N-acetylgalactosaminyltransferase; O-glycosylation; O-glycan; mucin
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A novel member of the human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (pp-GalNAc-T) gene family was cloned as a homolog of human pp-GalNAc-T7, and designated pp-GalNAe-T10. pp-GalNAc-T10 transcript was found in the small intestine, stomach, pancreas, ovary, thyroid gland and spleen. In a polypeptide GalNAc-transfer assay, recombinant pp-GalNAc-T10 transferred GalNAc onto a panel of mucin-derived peptide substrates. Furthermore, pp-GalNAe-T10 demonstrated strong transferase activity with glycopeptide substrates. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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